Vitros digoxin immunoassay evaluated for interference by digoxin-like immunoreactive factors.
نویسندگان
چکیده
by Digoxin-like Immunoreactive Factors, Barbara A. Way, Timothy R. Wilhite, Ralph Miller, Carl H. Smith, and Michael Landt (Departments of 1 Pediatrics and 2 Pathology, Washington University School of Medicine, St. Louis Children’s Hospital, and 3 BJC Health System, St. Louis, MO 63110; * author for correspondence: Department of Pediatrics, Washington University School of Medicine, St. Louis Children’s Hospital, One Children’s Place, St. Louis, MO 63110; fax 314-454-2274, e-mail [email protected])
منابع مشابه
A physician's office-based digoxin assay (Seralyzer) evaluated for interference by endogenous digoxin-like immunoreactive factors.
A digoxin test for a physician's office based-chemistry analyzer (Ames Seralyzer) was evaluated for possible interference by digoxin-like immunoreactive factors (DLIF). Sera from patients likely to have high concentrations of DLIF (renal and hepatic patients, pregnant women, and neonates) as well as from normal patients and umbilical cord blood were analysed by the Seralyzer digoxin immunoassay...
متن کاملEndogenous digoxin-like immunoreactive factors eliminated from serum samples by hydrophobic silica-gel extraction and enzyme immunoassay.
Elimination of endogenous digoxin-like immunoreactive factors (DLIF) that interfere with accurate measurement of digoxin requires use of a highly specific anti-digoxin antibody, or that DLIF be separated from digoxin before immunoassay. Several commercial digoxin-assay kits include a step for separating serum proteins and other substances from digoxin before immunoassay. We tested six different...
متن کاملDigoxin-like immunoreactivity in serum from neonates and infants reduced by centrifugal ultrafiltration and fluorescence polarization immunoassay.
We evaluated the TDx Digoxin II (Abbott) modified procedure for interference from digoxin-like immunoreactive factors (DLIF) in pediatric patients. The effectiveness of centrifugal ultrafiltration as a means of removing DLIF interference from the serum of such patients was assessed. We used sera from 40 patients who had not received digoxin, whom we divided into two age groups: 30 neonates (les...
متن کاملEffect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind.
CONTEXT Ashwagandha, a popular Ayurvedic medicine, is now available in the United States. Alkaloids found in this herb have structural similarity with digoxin. OBJECTIVE To study potential interference of Ashwagandha with serum digoxin measurement by immunoassays. Potential interference was also investigated with immunoassays for 11 other commonly monitored drugs. In addition, interaction of ...
متن کاملSeven different digoxin immunoassay kits compared with respect to interference by a digoxin-like immunoreactive substance in serum from premature and full-term infants.
Seven different digoxin immunoassay kits showed cross reactivity with an endogenous digoxin-like immunoreactive substance consistently present in serum of neonates, whether premature or full-term. The degree of interference, in decreasing order was: NML greater than New England Nuclear greater than Bio-Rad greater than Clinical Assays greater than Becton Dickinson greater than Serono greater th...
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عنوان ژورنال:
- Clinical chemistry
دوره 44 6 Pt 1 شماره
صفحات -
تاریخ انتشار 1998